Well when you install Centos 4.2 Server, your getting a striped down version of Linux. No GUI, bundled software, ect, it runs from the command line. Which means their is less security holes for your OS. Centos 4.2 Server is so small it fits on a single cd. If your not experienced with running Linux from the command line I wouldn't recommend it.
A desktop distro is a bloated version of Linux. Its loaded with a nice GUI, web browser, games, ect. Lots of room for security holes. You really wouldn't want to use it for a server unless it was a home webserver, or you were just learning Linux.
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